Rabbit models of cardiac mechano-electric and mechano-mechanical coupling
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منابع مشابه
Rabbit models of cardiac mechano-electric and mechano-mechanical coupling
Cardiac auto-regulation involves integrated regulatory loops linking electrics and mechanics in the heart. Whereas mechanical activity is usually seen as 'the endpoint' of cardiac auto-regulation, it is important to appreciate that the heart would not function without feed-back from the mechanical environment to cardiac electrical (mechano-electric coupling, MEC) and mechanical (mechano-mechani...
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From humble beginnings, cardiac mechanoelectric transduction or feedback has come of age. The last editorial board (Editor-in-Chief, David Hearse, and concerning the Focussed Issue particularly Associate Editor Michael Shattock) facilitated growth by encouraging the Issue. The present board (Editor-in-Chief, Michiel Janse, and concerning this focussed publication, Associate Editor Tobias Opthof...
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The heart beat is controlled by electrical excitation waves which propagate through the heart and initiate cardiac contraction. Contraction of the heart also affects the process of wave propagation resulting in a complex global feedback phenomenon known as mechanoelectrical feedback (MEF). MEF has been studied in electrophysiology for well over a century and may have both pro-arrhythmic and arr...
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At the most basic level, the heart is an electrically controlled pump. As such, our attention tends to focus on the feed-forward mechanisms by which cardiac excitation, occurring through co-ordinated ion channel activity, leads to the calcium signal necessary for contraction. Yet, it is becoming clear that the heart is intrinsically regulated, including feedback from its mechanical state to ion...
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BACKGROUND Mechanoelectric feedback (MEF) describes the modulation of electrical activity by mechanical activity. This may occur via the activation of mechanosensitive ion channels (MSCs). MEF has not previously been investigated in fish ventricular tissue even though fish can greatly increase ventricular end diastolic volume during exercise which should therefore provide a powerful mechanical ...
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ژورنال
عنوان ژورنال: Progress in Biophysics and Molecular Biology
سال: 2016
ISSN: 0079-6107
DOI: 10.1016/j.pbiomolbio.2016.05.003